Thursday, October 21, 2010

Cyclin Was Discovered 30 years ago - what is it being used for today?

It looks like research articles on cyclin have been published regularly over the past twenty years. In fact the 2001 Nobel Prize in Physiology or Medicine was awarded for the discovery of CDKs and cyclins and the complete description of cyclin and cyclin-dependent kinase mechanisms.

You remember from our textbook that when cyclin is injected into a non-dividing cell it begins to form spindles and goes into cell division. A research article published in 2008 found that cyclin d1 is over-expressed in human breast cancer. These findings may explain how cyclin d1 contributes to breast tumor growth, and provides the rationale for targeted therapies in humans.

In April 2010, over 50 abstracts were presented at the American Association of Cancer Research meeting dealing with cyclins and ways to inhibit the cyclin dependent kinase. It looks like a very promising area of cancer study.

Sources: ErbB2 Induces Notch1 Activity and Function in Breast Cancer Cells Clinical
and Translational Science Volume 1, Issue 2, pages 107–115, September 2008

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